show Abstracthide AbstractAlaska contains over 600 formerly used defense (FUD) sites, many of which serve as point sources of pollution. These sites are often co-located with rural communities that depend upon traditional subsistence foods, especially lipid-rich animals that bioaccumulate and biomagnify persistent organic pollutants (POPs). Many POPs are carcinogenic and endocrine-disrupting compounds that are associated with various adverse health outcomes. As a result, elevated exposure to POPs from point sources of pollution may contribute to disproportionate incidence of disease in arctic communities. We used the BIOO NEXTflex Rapid Directional qRNA-Seq Kit to generate strand-specific RNA-Seq libraries from Ninespine Stickleback and Alaska Blackfish collected from contaminated sites in Sivuqaq (St. Lawrence Island), Alaska.